Advancing mRNA Medicines to Fight and Prevent Disease

At Moderna, we are driven by our mission to deliver on the promise of mRNA science to create a new generation of transformative medicines for patients. We are currently advancing mRNA development candidates to address serious unmet needs across several therapeutic areas and multiple diseases. Clinical (human) trials are now underway for several of our investigational mRNA vaccines and therapeutics.

Below is a list of clinical trials for which Moderna is actively recruiting participants. We have provided links to the study listings on www.clinicaltrials.gov, where you can find more information, including details on eligibility criteria and clinical trial locations.

If you are seeking additional information, please email clinicaltrials@modernatx.com.

Actively Recruiting Clinical Studies
 

Prophylactic Vaccines


Disease Program Study Phase Study Focus More Info

Cytomegalovirus (CMV)

mRNA-1647

Phase 1

Safety, reactogenicity, and immunogenicity of Cytomegalovirus Vaccines mRNA-1647 in Healthy Adults

clinicaltrials.gov

 

Cancer Vaccines


Disease Program Study Phase Study Focus More Info
Solid tumors  

mRNA-4157

Phase 1 Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone in Subjects with Resected Solid Tumors and in Combination With Pembrolizumab in Subjects With Unresectable Solid Tumors (KEYNOTE-603) clinicaltrials.gov

 

Intratumoral Immuno-Oncology




Disease Program Study Phase Study Focus More Info
Advanced / metastatic
solid tumors
or lymphoma

mRNA-2416

Phase 1

Dose Escalation Study of mRNA-2416 for Intratumoral Injection to Patients with Advanced Malignancies

clinicaltrials.gov
Relapsed/Refractory
solid tumors
malignancies
or lymphoma

mRNA- 2752

Phase 1

Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Patients with Advanced Malignancies

clinicaltrials.gov

 

Systemic Secreted Therapeutics


Disease Program Study Phase Study Focus More Info
Chikungunya virus  

mRNA-1944

Phase 1 Safety, tolerability, pharmacokinetics and pharmacodynamics of mRNA-1944 in healthy adults clinicaltrials.gov

 

Systemic Intracellular Therapeutics



Disease Program Study Phase Study Focus More Info

Methylmalonic Acidemia

mRNA-3704

Phase 1/2

Open Label Study of mRNA-3704 in Patients With Isolated Methylmalonic Acidemia

clinicaltrials.gov

Methylmalonic Acidemia, Propionic Acidemia

mRNA-3704
mRNA-3927

Natural History Study

Longitudinal, exploratory, natural history
study of patients with MMA due to
mut deficiency and PA

clinicaltrials.gov