Advancing mRNA Medicines to Fight and Prevent Disease

At Moderna, we are driven by our mission to deliver on the promise of mRNA science to create a new generation of transformative medicines for patients. We are currently advancing mRNA development candidates to address serious unmet needs across several therapeutic areas and multiple diseases. Clinical (human) trials are now underway for several of our investigational mRNA vaccines and therapeutics.

Below is a list of clinical trials for which Moderna is actively recruiting participants. We have provided links to the study listings on www.clinicaltrials.gov, where you can find more information, including details on eligibility criteria and clinical trial locations.

If you are seeking additional information, please email clinicaltrials@modernatx.com.

Actively Recruiting Clinical Studies
 

Prophylactic Vaccines


Disease Program Study Phase Study Focus More Info
Cytomegalovirus (CMV)  

mRNA-1647

Phase 1 Safety, reactogenicity, and immunogenicity of Cytomegalovirus Vaccines mRNA-1647 in Healthy Adults clinicaltrials.gov

 

Cancer Vaccines


Disease Program Study Phase Study Focus More Info
Solid tumors  

mRNA-4157

Phase 1 Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone in Subjects with Resected Solid Tumors and in Combination With Pembrolizumab in Subjects With Unresectable Solid Tumors (KEYNOTE-603) clinicaltrials.gov
Melanoma  

mRNA-4157

Phase 2 An Efficacy Study of Adjuvant Treatment with the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Patients With High-Risk Melanoma (KEYNOTE-942) clinicaltrials.gov

 

Intratumoral Immuno-Oncology


Disease Program Study Phase Study Focus More Info
Advanced / metastatic
solid tumors
or lymphoma
 

mRNA-2416

Phase 1 Dose Escalation Study of mRNA-2416 for Intratumoral Injection to Patients with Advanced Malignancies clinicaltrials.gov
Relapsed/Refractory
solid tumors
malignancies
or lymphoma
 

mRNA-2752

Phase 1 Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Patients with Advanced Malignancies clinicaltrials.gov

 

Systemic Secreted Therapeutics


Disease Program Study Phase Study Focus More Info
Chikungunya virus  

mRNA-1944

Phase 1 Safety, tolerability, pharmacokinetics and pharmacodynamics of mRNA-1944 in healthy adults clinicaltrials.gov

 

Systemic Intracellular Therapeutics


Disease Program Study Phase Study Focus More Info
Methylmalonic Acidemia  

mRNA-3704

Phase 1/2 Open Label Study of mRNA-3704 in Patients With Isolated Methylmalonic Acidemia clinicaltrials.gov
Methylmalonic Acidemia, Propionic Acidemia  

mRNA-3704
mRNA-3927

Natural History Study Longitudinal, exploratory, natural history
study of patients with MMA due to
mut deficiency and PA
clinicaltrials.gov