Our development pipeline illustrates the progress we’re making on Moderna’s clinical programs currently in development to create mRNA medicines for a wide range of diseases and conditions. We are proud of the advancements we’ve made in pioneering new vaccines and therapeutics that may have the potential to treat rare diseases like Methylmalonic Acidemia (MMA) and Propionic Acidemia (PA), and prevent disease such as Cytomegalovirus (CMV), Zika and cancers. View the progress of our mRNA clinical pipeline below.

Modality
Program Indication
ID #
Preclinical development
Phase 1
Phase 2
Phase 3
Commercial
Moderna rights
Core modalities
Adults

COVID-19 vaccine

mRNA-1273
Progress: 100%
Progress: 100%
Progress: 100%
Progress: 100%
Progress: 60%

Worldwide
 

COVID-19 vaccine

mRNA-1273.351
Beta variant
Progress: 100%
Progress: 100%
Progress: 50%

Worldwide

COVID-19 vaccine

mRNA-1273.617
Delta variant
Progress: 100%
Progress: 100%
Progress: 50%

Worldwide

COVID-19 vaccine

mRNA-1273.211
Beta variant + wild-type
Progress: 100%
Progress: 100%
Progress: 50%

Worldwide

COVID-19 vaccine

mRNA-1273.213
Beta+Delta variant
Progress: 100%

Worldwide

COVID-19 vaccine

mRNA-1283
Next generation (2-5 ºC)
Progress: 100%
Progress: 50%

Worldwide

Flu vaccine

mRNA-1010
Phase 1/2
Progress: 100%
Progress: 100%
Progress: 100%
Progress: 50%

Worldwide

Flu vaccine

mRNA-1020
Progress: 75%

Worldwide

Flu vaccine

mRNA-1030
Progress: 75%

Worldwide

COVID + Flu vaccine

mRNA-1073
mRNA-1273
mRNA-1010
Progress: 75%

Worldwide

Respiratory syncytial virus (RSV) vaccine

mRNA-1345
Progress: 100%
Progress: 100%
Progress: 100%
Progress: 25%

Worldwide

Adolescents & Pediatrics

COVID-19 (adolescents)

mRNA-1273
TeenCOVE
Progress: 100%
Progress: 100%
Progress: 50%

Worldwide

COVID-19 vaccine (pediatrics)

mRNA-1273
KidCOVE
Progress: 100%
Progress: 100%
Progress: 50%

Worldwide

Pediatric RSV vaccine

mRNA-1345
Progress: 100%
Progress: 50%

Worldwide

Pediatric hMPV+PIV3 vaccine

mRNA-1653
Phase 1b
Progress: 100%
Progress: 95%

Worldwide

Pediatric RSV + hMPV vaccine

mRNA-1365
Progress: 75%

Worldwide

Latent Vaccines

CMV vaccine

mRNA-1647
Progress: 100%
Progress: 100%
Progress: 100%
Progress: 50%

Worldwide

Epstein-Barr virus (EBV) vaccine

mRNA-1189
Progress: 65%

Worldwide

EBV therapeutic vaccine

mRNA-1195
Progress: 65%

Worldwide

Prophylactic Vaccines

HIV vaccine

mRNA-1644
Open IND
Progress: 100%

Worldwide

IAVI/others funded

HIV vaccine

mRNA-1574
Progress: 65%

Worldwide

IAVI/BMGF/NIAID and others funded

Other Vaccines

Zika vaccine

mRNA-1893
Progress: 100%
Progress: 100%
Progress: 50%

Worldwide
BARDA funded

Nipah vaccine

mRNA-1215
Progress: 65%

Worldwide

NIH funded

Exploratory modalities
Systemic Secreted & Cell Surface Therapeutics

IL-2
Autoimmune disorders

mRNA-6231
Progress: 100%
Progress: 50%

Worldwide

Relaxin

mRNA-0184
Progress: 65%

Worldwide

PD-L1
Autoimmune hepatitis

mRNA-6981
Progress: 65%

Worldwide

Cancer Vaccines

Personalized cancer vaccine (PCV)

mRNA-4157
Progress: 100%
Progress: 100%
Progress: 50%

50-50 global profit sharing with Merck

KRAS vaccine

mRNA-5671
Progress: 100%
Progress: 50%

50-50 global profit sharing with Merck

Intratumoral Immuno-Oncology

OX40L/IL-23/IL-36γ (Triplet)
Solid tumors/lymphoma

mRNA-2752
Progress: 100%
Progress: 50%

Worldwide

IL-12
Solid tumors

MEDI1191
Progress: 100%
Progress: 50%

50-50 U.S. profit sharing; AZ to pay royalties on ex-U.S. sales

Localized Regenerative Therapeutics

VEGF-A
Myocardial ischemia

AZD8601
Progress: 100%
Progress: 100%
Progress: 75%

AZ to pay milestones and royalties

Systemic Intracellular Therapeutics

PCCA/PCCB
Propionic acidemia (PA)

mRNA-3927
Progress: 100%
Progress: 50%

Worldwide

MUT
Methylmalonic acidemia (MMA)

mRNA-3705
Progress: 100%
Progress: 50%

Worldwide

G6Pase
Glycogen Storage Disease
Type 1a (GSD1a)

mRNA-3745
Open IND
Progress: 100%

Worldwide

PAH
Phenylketonuria (PKU)

mRNA-3283
Progress: 65%

Worldwide

Crigler-Najjar Syndrome Type 1 (CN-1)

mRNA-3351
Progress: 65%

Provided by ILCM,
Institute for Life
Changing Medicines
free of charge

Inhaled Pulmonary Therapeutics

Cystic Fibrosis (CF)

VXc0522
Progress: 65%

Vertex to pay milestones and royalties

Abbreviations: AZ, AstraZeneca; CMV, cytomegalovirus; CRC, colorectal cancer; G6Pase, glucose 6-phosphatase; hMPV, human metapneumovirus; IL12, interleukin 12; IL23, interleukin 23; IL36γ, interleukin 36 gamma; MUT, methylmalonyl-CoA mutase; NSCLC, non-small cell lung cancer; PAH, phenylalanine hydroxylase; PCCA/PCCB, propionyl-CoA carboxylase subunit A/B; PCV, personalized cancer vaccine; PIV3, human parainfluenza 3; RSV, respiratory syncytial virus; VEGF-A, vascular endothelial growth factor A.