mRNA pipeline
Research
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Our mRNA pipeline shows the progress we’re making on clinical programs currently in development to create mRNA medicines for a wide range of diseases and conditions.
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Program Indication
ID #
Preclinical Development
Phase 1
Phase 2
Phase 3
Commercial
Moderna rights
Respiratory Vaccines
Adults
COVID-19 vaccine
mRNA-1273/Spikevax®
Commercial
Moderna rights:Worldwide
COVID-19 vaccineOmicron variant + wild-type
mRNA-1273.214
Commercial
Moderna rights:Worldwide
COVID-19 vaccineOmicron (BA.4/5) variant + wild-type
mRNA-1273.222
Commercial
Moderna rights:Worldwide
COVID-19 vaccineOmicron variant
mRNA-1273.529
Phase 3
Moderna rights:Worldwide
COVID-19 vaccineBeta variant
mRNA-1273.351
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineDelta variant
mRNA-1273.617
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineBeta variant + wild-type
mRNA-1273.211
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineBeta + Delta variant
mRNA-1273.213
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineNext generation (2-5 ºC)
mRNA-1283
Phase 2
Moderna rights:Worldwide
Flu vaccine
mRNA-1010
Phase 3
Moderna rights:Worldwide
Flu vaccine
mRNA-1020
Phase 1
Moderna rights:Worldwide
Flu vaccine
mRNA-1030
Phase 1
Moderna rights:Worldwide
Flu vaccine
mRNA-1011
Preclinical Development
Moderna rights:Worldwide
Flu vaccine
mRNA-1012
Preclinical Development
Moderna rights:Worldwide
Older adults respiratory syncytial virus (RSV) vaccine
mRNA-1345
Phase 3
Moderna rights:Worldwide
COVID + Flu vaccinemRNA-1273 mRNA-1010
mRNA-1073
Phase 1
Moderna rights:Worldwide
COVID + Flu + RSV vaccine
mRNA-1230
Phase 1
Moderna rights:Worldwide
Endemic HCoV vaccine
mRNA-1287
Preclinical Development
Moderna rights:Worldwide
Flu + RSV vaccine
mRNA-1045
Phase 1
Moderna rights:Worldwide
Adolescents and Pediatrics
COVID-19 (adolescents)TeenCOVE
mRNA-1273
Commercial
Moderna rights:Worldwide
COVID-19 vaccine (pediatrics)KidCOVE
mRNA-1273
Commercial
Moderna rights:Worldwide
Pediatric RSV vaccine
mRNA-1345
Phase 1
Moderna rights:Worldwide
Pediatric hMPV+PIV3 vaccine
mRNA-1653
Phase 1
Moderna rights:Worldwide
Pediatric RSV + hMPV vaccine
mRNA-1365
Preclinical Development
Moderna rights:Worldwide
Latent & Public Health Vaccines
Latent Vaccines
CMV vaccine
mRNA-1647
Phase 3
Moderna rights:Worldwide
EBV vaccine (to prevent infectious mononucleosis)
mRNA-1189
Phase 1
Moderna rights:Worldwide
EBV vaccine (to prevent long term EBV sequelae)
mRNA-1195
Preclinical Development
Moderna rights:Worldwide
HSV Vaccine
mRNA-1608
Preclinical Development
Moderna rights:Worldwide
VZV Vaccine
mRNA-1468
Preclinical Development
Moderna rights:Worldwide
HIV vaccine
mRNA-1644
Phase 1
Moderna rights:Worldwide IAVI/others funded
HIV vaccine
mRNA-1574
Phase 1
Moderna rights:Worldwide IAVI/BMGF/NIAID and others funded
Public Health Vaccines
Zika vaccine
mRNA-1893
Phase 2
Moderna rights:Worldwide BARDA funded
Nipah vaccine
mRNA-1215
Phase 1
Moderna rights:Worldwide NIH funded
Therapeutics
Systemic Secreted & Cell Surface Therapeutics
Relaxin
mRNA-0184
Phase 1
Moderna rights:Worldwide
PD-L1 Autoimmune hepatitis
mRNA-6981
Preclinical Development
Moderna rights:Worldwide
Cancer Vaccines
Personalized cancer vaccine (PCV)
mRNA-4157
Phase 2
Moderna rights:50-50 global profit sharing with Merck
KRAS vaccine
mRNA-5671
Phase 1
Moderna rights:Worldwide
Checkpoint Vaccine
mRNA-4359
Phase 1
Moderna rights:Worldwide
Intratumoral Immuno-Oncology
OX40L/IL-23/IL-36γ (Triplet) Solid tumors/lymphoma
mRNA-2752
Phase 1
Moderna rights:Worldwide
IL-12 Solid tumors
MEDI1191
Phase 1
Moderna rights:Worldwide
Localized Regenerative Therapeutics
VEGF-A Myocardial ischemia
AZD8601
Phase 2
Moderna rights:Worldwide
Systemic Intracellular Therapeutics
PCCA/PCCB Propionic acidemia (PA)
mRNA-3927
Phase 2
Moderna rights:Worldwide
MUT Methylmalonic acidemia (MMA)
mRNA-3705
Phase 1
Moderna rights:Worldwide
G6Pase Glycogen Storage Disease Type 1a (GSD1a)Open IND
mRNA-3745
Phase 1
Moderna rights:Worldwide
Ornithine transcarbamylase deficiency (OTC)
mRNA-3139
Preclinical Development
Moderna rights:Worldwide
PAH Phenylketonuria (PKU)
mRNA-3283
Preclinical Development
Moderna rights:Worldwide
Crigler-Najjar Syndrome Type 1 (CN-1)
mRNA-3351
Preclinical Development
Moderna rights:Provided by ILCM, Institute for Life Changing Medicines free of charge
Inhaled Pulmonary Therapeutics
Cystic Fibrosis (CF)
VX-522
Phase 1
Moderna rights:Vertex to pay milestones and royalties
Abbreviations:
AZ: AstraZeneca
CMV: cytomegalovirus
CRC: colorectal cancer
G6Pase: glucose 6-phosphatase
hMPV: human metapneumovirus
IL12: interleukin 12
IL23: interleukin 23
IL36γ: interleukin 36 gamma
MUT: methylmalonyl-CoA mutase
NSCLC: non-small cell lung cancer
PAH: phenylalanine hydroxylase
PCCA/PCCB: propionyl-CoA carboxylase subunit A/B
PCV: personalized cancer vaccine
PIV3: human parainfluenza 3
RSV: respiratory syncytial virus
VEGF-A: vascular endothelial growth factor A