Research
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Our product pipeline shows the progress we’re making on clinical programs currently in development to create mRNA medicines for a wide range of diseases and conditions. We are proud of the advancements we’ve made in pioneering new mRNA vaccines and treatments that may have the potential to treat and prevent rare diseases.
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Program Indication
ID #
Preclinical Development
Phase 1
Phase 2
Phase 3
Commercial
Moderna rights
Respiratory Vaccines
Adults
COVID-19 vaccine
mRNA-1273/Spikevax®
Commercial
Moderna rights:Worldwide
COVID-19 vaccineBeta variant
mRNA-1273.351
Phase 1
Moderna rights:Worldwide
COVID-19 vaccineDelta variant
mRNA-1273.617
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineBeta variant + wild-type
mRNA-1273.211
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineBeta + Delta variant
mRNA-1273.213
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineOmicron variant
mRNA-1273.529
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineOmicron variant + wild-type
mRNA-1273.214
Phase 2
Moderna rights:Worldwide
COVID-19 vaccineNext generation (2-5 ºC)
mRNA-1283
Phase 2
Moderna rights:Worldwide
Flu vaccine
mRNA-1010
Phase 3 Prep
Phase 2
-Phase 3 Prep
Moderna rights:Worldwide
Flu vaccine
mRNA-1011
Preclinical Development
Moderna rights:Worldwide
Flu vaccine
mRNA-1012
Preclinical Development
Moderna rights:Worldwide
Flu vaccine
mRNA-1020
Phase 1
Moderna rights:Worldwide
Flu vaccine
mRNA-1030
Phase 1
Moderna rights:Worldwide
COVID + Flu vaccinemRNA-1273 mRNA-1010
mRNA-1073
Preclinical Development
Moderna rights:Worldwide
Older adults respiratory syncytial virus (RSV) vaccine
mRNA-1345
Phase 3
Moderna rights:Worldwide
COVID + Flu + RSV vaccine
mRNA-1230
Preclinical Development
Moderna rights:Worldwide
Endemic HCoV vaccine
mRNA-1287
Preclinical Development
Moderna rights:Worldwide
Adolescents and Pediatrics
COVID-19 (adolescents)TeenCOVE
mRNA-1273
Phase 3
Moderna rights:Worldwide
COVID-19 vaccine (pediatrics)KidCOVE
mRNA-1273
Phase 3
Moderna rights:Worldwide
Pediatric RSV vaccine
mRNA-1345
Phase 1
Moderna rights:Worldwide
Pediatric hMPV+PIV3 vaccine
mRNA-1653
Phase 1
Moderna rights:Worldwide
Pediatric RSV + hMPV vaccine
mRNA-1365
Preclinical Development
Moderna rights:Worldwide
Latent & Public Health Vaccines
Latent Vaccines
CMV vaccine
mRNA-1647
Phase 3
Moderna rights:Worldwide
EBV vaccine (to prevent infectious mononucleosis)
mRNA-1189
Phase 1
Moderna rights:Worldwide
EBV vaccine (to prevent long term EBV sequelae)
mRNA-1195
Preclinical Development
Moderna rights:Worldwide
HSV Vaccine
mRNA-1608
Preclinical Development
Moderna rights:Worldwide
VZV Vaccine
mRNA-1468
Preclinical Development
Moderna rights:Worldwide
HIV vaccine
mRNA-1644
Phase 1
Moderna rights:Worldwide IAVI/others funded
HIV vaccine
mRNA-1574
Phase 1
Moderna rights:Worldwide IAVI/BMGF/NIAID and others funded
Public Health Vaccines
Zika vaccine
mRNA-1893
Phase 2
Moderna rights:Worldwide BARDA funded
Nipah vaccine
mRNA-1215
Preclinical Development
Moderna rights:Worldwide NIH funded
Therapeutics
Systemic Secreted & Cell Surface Therapeutics
IL-2 Autoimmune disorders
mRNA-6231
Phase 1
Moderna rights:Worldwide
Relaxin
mRNA-0184
Preclinical Development
Moderna rights:Worldwide
PD-L1 Autoimmune hepatitis
mRNA-6981
Preclinical Development
Moderna rights:Worldwide
Cancer Vaccines
Personalized cancer vaccine (PCV)
mRNA-4157
Phase 2
Moderna rights:50-50 global profit sharing with Merck
KRAS vaccine
mRNA-5671
Phase 1
Moderna rights:Worldwide
Checkpoint Vaccine
mRNA-4359
Preclinical Development
Moderna rights:Worldwide
Intratumoral Immuno-Oncology
OX40L/IL-23/IL-36γ (Triplet) Solid tumors/lymphoma
mRNA-2752
Phase 1
Moderna rights:Worldwide
IL-12 Solid tumors
MEDI1191
Phase 1
Moderna rights:50-50 U.S. profit sharing; AZ to pay royalties on ex-U.S. sales
Localized Regenerative Therapeutics
VEGF-A Myocardial ischemia
AZD8601
Phase 2
Moderna rights:AZ to pay milestones and royalties
Systemic Intracellular Therapeutics
PCCA/PCCB Propionic acidemia (PA)
mRNA-3927
Phase 1
Moderna rights:Worldwide
MUT Methylmalonic acidemia (MMA)
mRNA-3705
Phase 1
Moderna rights:Worldwide
G6Pase Glycogen Storage Disease Type 1a (GSD1a)Open IND
mRNA-3745
Preclinical Development
Moderna rights:Worldwide
PAH Phenylketonuria (PKU)
mRNA-3283
Preclinical Development
Moderna rights:Worldwide
Crigler-Najjar Syndrome Type 1 (CN-1)
mRNA-3351
Preclinical Development
Moderna rights:Provided by ILCM, Institute for Life Changing Medicines free of charge
Inhaled Pulmonary Therapeutics
Cystic Fibrosis (CF)
VXc-522
Preclinical Development
Moderna rights:Vertex to pay milestones and royalties
Abbreviations:
AZ: AstraZeneca
CMV: cytomegalovirus
CRC: colorectal cancer
G6Pase: glucose 6-phosphatase
hMPV: human metapneumovirus
IL12: interleukin 12
IL23: interleukin 23
IL36γ: interleukin 36 gamma
MUT: methylmalonyl-CoA mutase
NSCLC: non-small cell lung cancer
PAH: phenylalanine hydroxylase
PCCA/PCCB: propionyl-CoA carboxylase subunit A/B
PCV: personalized cancer vaccine
PIV3: human parainfluenza 3
RSV: respiratory syncytial virus
VEGF-A: vascular endothelial growth factor A